Publications by authors named "E T G Kersten"
Background: Long-acting beta2-agonists (LABA) in combination with inhaled corticosteroids (ICS) are commonly used to treat asthma, however, some children lack response to the addition of LABA. This might be partially due to the presence of the Arg16Gly polymorphism, encoded by rs1042713 G>A in the ADRB2 gene. Carrying the A allele (Arg16) at this variant has been associated with an increased risk of exacerbations despite LABA treatment.
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- The review covers the genetic and epigenetic factors related to food allergies, including their inheritance and the advantages and limitations of study methods.
- Genome-wide association studies have identified 16 significant genetic variants linked to food allergies, often overlapping with other allergic conditions.
- The article emphasizes the importance of integrating genetic and epigenetic data for understanding disease mechanisms and suggests future implications for predicting food allergy risks and responses to treatment.
Background: Little is known about the genetics of food allergy (FA) to various allergens and the heterogeneity of FA in adults.
Objective: We aimed to investigate genetic susceptibility to FA in an adult population and to assess the association between secondary FA and allergic rhinitis (AR).
Methods: FA and allergen-specific FA were defined based on in-depth questionnaires and a previously published FA algorithm in the Lifelines.
Genetics of preschool wheeze and its progression to childhood asthma.
Pediatr Allergy Immunol
January 2024
Wheezing is a common and heterogeneous condition in preschool children. In some countries, the prevalence can be as high as 30% and up to 50% of all children experience wheezing before the age of 6. Asthma often starts with preschool wheeze, but not all wheezing children will develop asthma at school age.
View Article and Find Full Text PDFBackground: Smoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (<1 year), persistence of differential methylation from in utero smoking exposure, and effects of environmental tobacco smoke (ETS).
Methods: We meta-analysed data from up to 15,014 adults across 5 cohorts with DNA methylation measured in blood using Illumina's EPIC array for current smoking (2560 exposed), quit < 1 year (500 exposed), in utero (286 exposed), and ETS exposure (676 exposed). We also evaluated the interaction of current smoking with sex or diet (fibre, folate, and vitamin C).