Publications by authors named "E T Coffey"
Article Synopsis
- - The SingWell Project aims to investigate whether group singing can improve speech-in-noise perception and overall mental health in older adults experiencing unaddressed hearing loss, addressing gaps in previous studies.
- - The study will involve 210 participants aged 60 and above, who will be randomly assigned to either a group singing program or an audiobook club for 12 weeks, with various assessments conducted throughout.
- - Researchers anticipate that engaging in group singing will significantly enhance both communication abilities in noisy environments and participants' psychosocial wellbeing.
Article Synopsis
- - Sleep spindles are brain oscillations that occur during sleep, and while they play a known role in memory consolidation, their effect on sleep continuity and memory protection is still being studied.
- - One theory suggests that spindles act as a gate, preventing external sensory information from reaching the brain's cortex, while another theory claims that spindles don't suppress sound-related responses, even though they can occur in response to sounds.
- - Research using EEG and MEG shows that auditory processing continues to some extent during sleep spindles and the brief refractory periods that follow them, providing new insights into how our brains manage sounds while we sleep.
Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial formulation combined with covalent conjugation may hide the oligonucleotide content and simultaneously enhance the role of appropriate conjugate groups on the outer sphere. The conjugate halo may be modulated to affect the delivery properties of the MSNAs.
View Article and Find Full Text PDFHeterozygous de novo loss of function variants in the motor domain of KIF5C are associated with a neurodevelopmental disorder characterized by infantile-onset epilepsy, frontal cortical dysplasia, and developmental delays including motor and speech impairments. Previously, only three missense variants in KIF5C were known to be pathogenic. We identified an additional six patients with significant developmental delays with heterozygous de novo variants in the KIF5C gene (Glu237Val, Thr93Ile, Thr93Asn, Ser90del, Lys92Arg, and Glu237Lys), of which four variants have not been reported before.
View Article and Find Full Text PDFWhen exposed to rhythmic stimulation, the human brain displays rhythmic activity across sensory modalities and regions. Given the ubiquity of this phenomenon, how sensory rhythms are transformed into neural rhythms remains surprisingly inconclusive. An influential model posits that endogenous oscillations entrain to external rhythms, thereby encoding environmental dynamics and shaping perception.
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