Role of the androgen receptor in melanoma aggressiveness.

Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. Novel therapies targeting receptor tyrosine kinases, kinases and immune checkpoints have been employed with a significant improvement of the overall survival and long-term disease containment. Nevertheless, the disease often progresses and becomes resistant to the therapies.

The Greater the Number of Altered Eating Behaviors in Obesity, the More Severe the Psychopathology.

: Altered eating behaviors (AEBs) are not only associated with eating disorders but also play a role in obesity. This study assessed AEBs in individuals with obesity and their association with general and eating psychopathology, using the "Eating Behaviors Assessment for Obesity" (EBA-O). The hypothesis posited that a higher frequency of pathological eating behaviors would correlate with more severe psychopathology.

Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome.

β-Caryophyllene (BCP) is a naturally occurring sesquiterpene found in numerous plant species, including Cannabis sativa. BCP has shown a high safety profile and a wide range of biological functions, including beneficial effects in neurodegenerative and inflammatory diseases. Here, we used behavioral, pharmacological, and in-silico docking analyses to investigate the effects and mechanism of action of BCP in Fragile X Syndrome (FXS), the most common inherited cause of Autism Spectrum Disorder (ASD) and intellectual disability.

TRPC5: a new entry to the chromaffin cell's palette of ion channels that control adrenal response to hypoglycemia.

Regulation of glucose levels during insulin-evoked hypoglycemia is impaired in patients with diabetes and can lead to a condition called hypoglycemia-associated autonomic failure (HAAF). The underlying mechanism of the reduced sympathoadrenal response in HAAF patients to counteract hypoglycemia is not yet clarified. In this issue of , Bröker-Lai et al, show that mice lacking TRPC5 channels possess an impaired response to insulin-induced hypoglycemia similar to humans with HAAF.

Does Cognitive Stimulation Therapy show similar efficacy in individuals with mild-to-moderate dementia from varying etiologies? An examination comparing its effectiveness in Alzheimer's disease and vascular dementia.

Objective: The effectiveness of the Cognitive Stimulation Therapy (CST) is well-documented. Nevertheless, the question of whether specific subgroups of individuals with dementia are more or less likely to benefit from this cognitive stimulation intervention remains unaddressed. Here, we directly compared the effectiveness of the Italian CST (CST-IT), delivered in a previous multicenter controlled clinical trial, across two distinct cohorts of individuals clinically diagnosed with Alzheimer's Disease (AD, = 30) and vascular dementia (VaD, = 27) in the mild-to-moderate stage.