Publications by authors named "E T CARLSON"
High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.
View Article and Find Full Text PDFIntroduction: We investigated whether the cerebellum develops neuropathology that correlates with well-accepted Alzheimer's disease (AD) neuropathological markers and cognitive status.
Methods: We studied cerebellar cytoarchitecture in a cohort (N = 30) of brain donors. In a larger cohort (N = 605), we queried whether the weight of the contents of the posterior fossa (PF), which contains primarily cerebellum, correlated with dementia status.
Article Synopsis
- - Penicillin-binding proteins (PBPs) are crucial bacterial enzymes that can be inhibited by β-lactam antibiotics, disrupting their ability to grow and divide, ultimately leading to cell lysis.
- - Traditional metrics like IC values for measuring enzyme inhibition can be misleading, especially for covalent inhibitors, making the second-order rate constant (k) a better measure of potency.
- - The researchers created a whole-cell k assay using a fluorescent probe to assess β-lactam potency across multiple PBPs, confirming its effectiveness in relation to existing IC values and supporting further structure-activity relationship studies.
Excessive alcohol use damages the brain, especially corticolimbic regions such as the hippocampus and rhinal cortices, leading to learning and memory problems. While neuroimmune reactivity is hypothesized to underly alcohol-induced damage, direct evidence of the causative role of microglia, brain-resident immune cells, in this process is lacking. Here, we depleted microglia using PLX5622 (PLX), a CSF1R inhibitor commonly used in mice, but rarely in rats, and assessed cell death following binge-like alcohol exposure in male rats.
View Article and Find Full Text PDFArticle Synopsis
- * In a four-week challenge, 46 medical students engaged in health screenings and nutrition seminars, resulting in significant weight loss and reductions in blood pressure.
- * Results showed a strong push from participants for more nutrition education in medical schools, indicating that integrating such topics could enhance long-term patient health outcomes.