Publications by authors named "E Szczepanek-Parulska"

Gaucher disease (GD), the most common ultra-rare metabolic disorder, results from lipid accumulation. Systemic inflammation, cellular stress, and metabolic dysfunction may influence endocrine function, including the thyroid. This study evaluated thyroid function and morphology in 60 GD patients, alongside carbohydrate and lipid metabolism.

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Introduction: Differentiated thyroid cancer (DTC) is the most common type of endocrine malignancy, with rising incidence over recent decades. Despite a favorable prognosis, DTC management remains complex, often involving thyroidectomy followed by radioactive iodine (RAI) therapy. While RAI is crucial for patient outcomes, its efficacy varies, necessitating the identification of predictors for treatment response.

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Article Synopsis
  • The study examines the potential of serum CD5L, a liver-derived protein, as an additional biomarker for assessing thyroid hormone (TH) status during pregnancy, where routine markers may change.
  • Researchers developed a sensitive assay to measure CD5L levels and investigated factors that might influence its concentrations, finding that it remained stable and unaffected by circadian rhythms or liver disease.
  • Results showed that CD5L positively correlated with free triiodothyronine (fT3) and trace elements like selenium and copper in pregnant women, suggesting its potential usefulness as a reliable TH status indicator, especially in pregnancy and thyroid-related conditions.
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Background: Primary hyperparathyroidism is a common endocrine disorder characterised by excessive parathormone secretion that results in hypercalcemia, primarily caused by parathyroid adenoma. Accurate localisation of hyperfunctioning tissue is essential for curative surgical treatment. Although conventional imaging modalities like ultrasonography and Tc-MIBI scintigraphy (SPECT) along with F-fluorocholine PET/CT are commonly employed, there are cases with false-negative imaging results.

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Elevated immunoglobulin G4 (IgG4) serum antibodies are an important feature of IgG4-related disease. However, IgG4 antibodies can play a role in autoimmune thyroid disorders. In this study, we aimed to evaluate the impact of serum IgG4 levels on clinical features of Graves' disease (GD).

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