Publications by authors named "E Szabova"
Background: Gastroschisis is a serious birth defect with midgut prolapse into the amniotic cavity. The objectives of this study were to evaluate the prevalence and time trends of gastroschisis among programs in the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), focusing on regional variations and maternal age changes in the population.
Methods: We analyzed data on births from 1980 to 2017 from 27 ICBDSR member programs, representing 24 countries and three regions (Europe , Latin America, North America).
Article Synopsis
- The study estimates the global prevalence and mortality rates of cleft lip with cleft palate (CLP) using data from various birth defect registries from 1974 to 2014.
- The overall prevalence of CLP was found to be 6.4 cases per 10,000 births, with variations noted by region and pregnancy outcomes, particularly higher elective terminations in Europe.
- Survival rates for CLP were generally high at 91%, with isolated cases showing 97.7% survival, while those with multiple anomalies had lower survival rates of 77.1%, and genetic syndromes marked a further decline to 40.9%.
Article Synopsis
- The study analyzed data from various birth defect surveillance programs across 18 countries to assess the prevalence and mortality rates of anorectal malformation (ARM) between 1974 and 2014.
- The overall prevalence of ARM was found to be 3.26 cases per 10,000 births, with a notable decrease in cases that were multiple, syndromic, or stillborn from 2001 to 2012.
- The research highlights a significant mortality risk during the first week of life, especially in multiple and syndromic cases, suggesting a need for tailored clinical services and further investigation into factors affecting ARM prevalence and mortality.
Article Synopsis
- Bladder exstrophy (BE) is a rare birth defect impacting the lower abdomen; this study investigates its prevalence, trends, and age-specific mortality rates using data from 20 surveillance programs across 16 countries from 1974 to 2014.
- The overall prevalence of BE was found to be 2.58 cases per 100,000 births, with a noticeable decline in prevalence between 2000 and 2014; first-week mortality rates were particularly high for multiple and syndromic cases, especially among cases from Latin America lacking elective termination options.
- The findings emphasize the importance of monitoring prevalence trends and addressing the elevated mortality risks in affected individuals, particularly in specific regions and among certain case
Article Synopsis
- Congenital hydrocephalus (CH) is a diverse set of birth defects with varying prevalence, and this study aimed to analyze the early neonatal case fatality rate (CFR) and total birth prevalence (BPR) among newborns with CH using data from 25 international registries from 2000 to 2014.
- The study found that the early neonatal CFR was 5.9 per 100 liveborn CH cases, with syndromic cases having a significantly higher CFR than non-syndromic cases (10.4% vs. 4.4%).
- Although there were substantial differences in CFR and BPR across registries, higher CFR often correlated with higher BPR; however, most