Polyprenylated Benzoylphloroglucinols Isolated from Species and Their Cytotoxic Effects on Cancer Cell Lines.

Polyprenylated benzoylphloroglucinols (PPBPs) make up a group of complex natural products with anticancer potentials that are mainly distributed in plants. As part of our intensive exploration on new bioactive substances from this genus, we report two undescribed PPBPs, picrorhizones I () and J (), along with four known analogues (-) from the stem bark of and . The new structures were elucidated on the basis of spectroscopic analysis, particularly 1D and 2D NMR and HRESIMS, whereas the absolute configurations were determined by a combination of ECD and NMR calculations coupled with a DP4+ probability analysis.

Cytotoxic prenylated xanthone derivatives from the twigs of .

A new prenylated xanthone, kaennacowanol D (), was isolated from the twigs of together with 22 known analogs. The structure of the new metabolite was elucidated by extensive spectroscopic analysis, particularly using HRMS and NMR. Kaennacowanol D is the first example of a natural xanthone containing a levulinyl group incorporated at the terminal prenyl unit ester bond.

A new benzoquinone and a new stilbenoid from (Ridl.) Rolfe.

One new alkyl benzoquinone, paphionone (), one new stilbenoid, ()-6,5'-dihydroxy-2,3'-dimethoxystilbene (), and eight known stilbenoids and flavonoids (-) were isolated from the leaves and roots of (Orchidaceae). Their chemical structures were determined based on IR, ECD, MS and NMR analyses. Cytotoxicity of all isolated compounds towards human hepatocellular carcinoma (HepG2) cell line was examined by MTT assay.

Two new rotenoid glycosides from the rhizomes of Hook. f.

Two new rotenoid glycosides named stemonal 11---D-glucopyranoside and 6--methylstemonal 11---D-glucopyranoside together with ten known metabolites were isolated from the rhizomes of . The chemical structures of the new compounds were elucidated based on the analysis of their 1D and 2D NMR and HRESIMS, while the sugar unit and absolute configuration were determined by chemical hydrolysis and ECD analysis. Among the tested compounds for anti-α-glucosidase assay, stemonal showed an inhibitory effect (IC = 38.

Cucumber ( L.) Fruit and Combination with Losartan Attenuate the Elevation of Blood Pressure in Hypertensive Rats Induced by Angiotensin II.

Objectives: L. () is vegetable commonly used for managing blood pressure and often consumed in combination with standard antihypertensive therapy, despite lack of scientific evidence supporting their use. Combination of herbs and standard medication could have positive or negative effects.