Synthesis of amide derivatives of 5,5-diphenylhydantoin as potential antiarrhythmic agents. I.

5,5-Diphenylhydantoin derivatives containing amide groups at the position 3 were synthesized as potential antiarrhythmic agents. The most valuable was (X) whose antiarrhythmic activity is stronger than that of phenytoin.

Pharmacological properties of 3-aminoalkyl and amide derivatives of 5,5-diphenylhydantoin.

5,5-Diphenylhydantoin derivatives containing at the position 3 aminoalkyl (1, 2, 4, 5), aminohydroxyalkyl (3) and amide (6, 8) groups were synthesized. The compounds, given in a dose of 50 mg/kg, did not affect cardiac bioelectric activity and, in contrast to diphenylhydantoin, did not possess the antiarrhythmic properties and did not protect against pentetrazol seizures.