CGP12177-induced haemodynamic and vascular effects in normotensive and hypertensive rats.

CGP12177 is a non-conventional partial agonist, known to have cardiostimulating and vasorelaxant properties related to its agonist action on the low affinity state of the beta(1)-adrenoceptor (beta(1LA)-adrenoceptor). In normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR), CGP12177-induced vasorelaxant effects were analysed in hindquarter vessels to assess modifications in hind limb vascular resistance, and in femoral artery rings. The global haemodynamic effects induced by CGP12177 were also investigated using telemetry in conscious animals.

[Epidemiological observations on the evolution of influenza in the city of Iaşi in the epidemic season of 1993-1994].

The epidemiological, clinical and laboratory data of influenza and other respiratory diseases recorded during the epidemic season 1993-1994, as they resulted from the comparative analysis of the cases reported weekly and those recorded through the "sentinel" collectivities method, are presented. The findings at admissions to the Infectious Diseases Hospital, Military Hospital, Diagnosis and Treatment Centre for Pupils and Students and the solicitation for medical care at the Emergency Ambulance Service were also interpreted. The involvement of A/Beijing/32/92/(H3N2) influenza virus was confirmed by evidencing the seroconversion on two serum samples tested through RIH, while for others antigens anamnestic reactions were recorded.

[The measurement of proteins with major involvement in the immunological process in a group of 100 elderly patients].

Alpha-2-macroglobulin, alpha-1-antitrypsin and prealbumin were studied comparatively in 100 patients aged between 60 and 90 years and a series of patients aged 25-45 years. Prealbumin was low in both groups, alpha-2-macroglobulin was higher and alpha-1-antitrypsin was lower in the elderly patients.

[Factors with an anti-infectious role and immunologic involvement in a group of 100 elderly patients compared with a group of young patients].

From the study of the immunological aspects in the elderly it is noticed a marked decrease of: complement C3 fraction, and lysosime and the insignificant decrease of creatininephosphokinase.