Publications by authors named "E Stinckens"
Bisphenol A alternatives are manufactured as potentially less harmful substitutes of bisphenol A (BPA) that offer similar functionality. These alternatives are already in the market, entering the environment and thus raising ecological concerns. However, it can be expected that levels of BPA alternatives will dominate in the future, they are limited information on their environmental safety.
View Article and Find Full Text PDFIn past times, the analysis of endocrine disrupting properties of chemicals has mainly been focused on (anti-)estrogenic or (anti-)androgenic properties, as well as on aspects of steroidogenesis and the modulation of thyroid signaling. More recently, disruption of energy metabolism and related signaling pathways by exogenous substances, so-called metabolism-disrupting chemicals (MDCs) have come into focus. While general effects such as body and organ weight changes are routinely monitored in animal studies, there is a clear lack of mechanistic test systems to determine and characterize the metabolism-disrupting potential of chemicals.
View Article and Find Full Text PDFCurrent test strategies to identify thyroid hormone (TH) system disruptors are inadequate for conducting robust chemical risk assessment required for regulation. The tests rely heavily on histopathological changes in rodent thyroid glands or measuring changes in systemic TH levels, but they lack specific new approach methodologies (NAMs) that can adequately detect TH-mediated effects. Such alternative test methods are needed to infer a causal relationship between molecular initiating events and adverse outcomes such as perturbed brain development.
View Article and Find Full Text PDFArticle Synopsis
- The evaluation of chemicals using early-life stage zebrafish has shown significant variation in reported phenotypes among researchers, highlighting the need for consistent terminology and data standards in toxicological studies.
- By applying standardized phenotype terminology via the Zebrafish Phenotype Ontology, a recent study found that data consistency improved and ambiguity decreased when researchers analyzed zebrafish larvae for malformations.
- A larger-scale study is needed to confirm these findings, but establishing a common data standard is recommended to enhance agreement and repeatability across different laboratories, paving the way for a zebrafish phenotype atlas.