Publications by authors named "E Stelling"
The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e.
View Article and Find Full Text PDFCardiac levels of the signal transducer and activator of transcription factor-3 (STAT3) decline with age, and male but not female mice with a cardiomyocyte-specific STAT3 deficiency conditional knockout (CKO) display premature age-related heart failure associated with reduced cardiac capillary density. In the present study, isolated male and female CKO-cardiomyocytes exhibit increased prostaglandin (PG)-generating cyclooxygenase-2 (COX-2) expression. The PG-degrading hydroxyprostaglandin-dehydrogenase-15 (HPGD) expression is only reduced in male cardiomyocytes, which is associated with increased prostaglandin D2 (PGD2) secretion from isolated male but not female CKO-cardiomyocytes.
View Article and Find Full Text PDFArticle Synopsis
- Peripartum cardiomyopathy (PPCM) is a serious heart condition that affects women with no prior heart issues, and is linked to the 16 kDa-prolactin fragment that causes vascular damage and heart failure.
- In a study comparing healthy postpartum women to those with PPCM, PAI-1 levels were significantly higher in PPCM patients at baseline but decreased after six months, coinciding with an improvement in heart function (LVEF).
- The researchers found that increased miR-146a levels in PPCM patients correlated with elevated PAI-1 and was associated with higher NF-κB activation in endothelial cells, suggesting a role of PAI-1 in the disease's underlying mechanisms.
Evaluation of the spinal pain score in AS--a psychometric analysis.
Rheumatology (Oxford)
December 2012
Objective: To evaluate the spinal pain score (SpiPS), a semi-objective instrument for measuring disease activity in AS.
Methods: The SpiPS is based on the physical examination of the spine and was evaluated according to the outcome measures in rheumatology filter in 659 AS patients from different cohorts including two interventional trials. Aspects of truth, discrimination and feasibility were assessed.
Aim: Evaluation of the effectiveness of radiosynoviorthesis (RSO) in osteoarthritis and other disorders with concomitant synovitis versus rheumatoid arthritis by means of a standardized questionnaire.
Patients, Methods: 803 RSO treatments were monitored in 691 patients by standardized questionnaires of 7 centers in 3 countries. Patients were assigned to 3 groups according to their age (20-40, 41-60, 61-80 years).