What do I need to know about glycopeptide antibiotics?

Glycopeptides have been crucial in the fight against Gram-positive pathogens with their use within paediatrics becoming ever prevalent. This article reviews the pharmacology of the commonly used glycopeptides, vancomycin and teicoplanin, and discusses the practical aspects of their use in the clinical setting.

A practitioner's guide for exploring water quality patterns using principal components analysis and Procrustes.

To design sustainable water quality monitoring programs, practitioners must choose meaningful variables, justify the temporal and spatial extent of measurements, and demonstrate that program objectives are successfully achieved after implementation. Consequently, data must be analyzed across several variables and often from multiple sites and seasons. Multivariate techniques such as ordination are common throughout the water quality literature, but methods vary widely and could benefit from greater standardization.