Unseen Enemy: Mechanisms of Multidrug Antimicrobial Resistance in Gram-Negative ESKAPE Pathogens.

Multidrug antimicrobial resistance (AMR) represents a formidable challenge in the therapy of infectious diseases, triggered by the particularly concerning gram-negative , , , , , and spp. (ESKAPE) pathogens. Designated as a "priority" in 2017, these bacteria continue to pose a significant threat in 2024, particularly during the worldwide SARS-CoV-2 pandemic, where coinfections with ESKAPE members contributed to worsened patient outcomes.

Stability and SERS signal strength of laser-generated gold, silver, and bimetallic nanoparticles at different KCl concentrations.

Noble metal nanoparticles, specifically gold and silver, are extensively utilized in sensors, catalysts, surface-enhanced Raman scattering (SERS), and optical-electronic components due to their unique localized surface plasmon resonance (LSPR) properties. The production of these nanoparticles involves various methods, but among the environmentally friendly approaches, laser ablation stands out as it eliminates the need for toxic chemicals during purification. However, nanoparticle aggregation poses a challenge in laser ablation, necessitating the addition of extra materials that contaminate the otherwise clean process.

Assessment of Plaque Characteristics by Contrast-Enhanced Ultrasound and Stent Restenosis following Carotid Artery Stenting: A Retrospective Study.

carotid artery stenosis contributes significantly to ischemic strokes, with management options including carotid endarterectomy (CEA) and carotid artery stenting (CAS) ischemic stroke risk can be reduced. Controversies persist regarding their efficacy and factors influencing complications, and understanding the relationship between atherosclerotic plaque characteristics and stent restenosis after CAS is crucial. we conducted a retrospective study involving 221 patients who underwent CAS for symptomatic or asymptomatic carotid artery stenosis.