Publications by authors named "E Stanca"
N-myc downstream-regulated gene 1 (NDRG1) is a member of the NDRG family of intracellular proteins and plays a central role in a wide range of biological processes including stress response, differentiation, and metabolism. The overexpression of NDRG1 is an indicator of poor prognosis in various types of cancer. Here, we found that NDRG1 is an independent prognostic marker of poor outcome in breast cancer (BC).
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- Lipotoxicity is harmful for metabolic health due to excess fatty acids, with palmitic acid (PA) causing more damage compared to oleic acid (OA) in liver cells.
- The study found that PA induces lipotoxicity, ER stress, and inhibits autophagy, leading to lower levels of DGAT1, an enzyme crucial for fat synthesis, while OA does not have the same effect.
- The research suggests that targeting DGAT1 and using PPARα agonists could offer new therapeutic strategies to mitigate the negative impacts of palmitic acid on liver health.
Article Synopsis
- This study investigates how N-methylpyridinium (NMP), an alkaloid found in coffee, affects lipid metabolism in liver cells influenced by Type 2 diabetes and nonalcoholic fatty liver diseases (NAFLDs).
- NMP was tested in a diabetes cell model, showing that it reduces lipid droplet accumulation and regulates gene expression related to lipogenesis by improving cellular oxidative status and endoplasmic reticulum (ER) stress response.
- The findings indicate that NMP could be beneficial for managing Type 2 diabetes and NAFLD by enhancing lipid metabolism and restoring cellular homeostasis.
Article Synopsis
- CACT is an important protein that helps transport long-chain fatty acids into mitochondria for energy production, and this study focuses on how its gene regulation is affected by omega-3 fatty acids (EPA and DHA).
- In liver cells, EPA and DHA were found to increase the levels of CACT mRNA and protein, highlighting their role in promoting this gene's expression.
- The research identified a specific region in the CACT promoter that responds to n-3 PUFAs, involving GABP proteins rather than PPARα, suggesting that GABP may play a key role in the activation of the CACT gene by these fatty acids.
Article Synopsis
- N-methylpyridinium (NMP) is created during coffee roasting from trigonelline and has potential health benefits due to its antioxidant properties.
- Preliminary studies have shown that NMP may protect against LPS-induced neuroinflammation in human glioblastoma cells by reducing pro-inflammatory cytokines and inhibiting the NF-κB signaling pathway.
- This research suggests that drinking coffee, which contains NMP, could help protect against neuroinflammatory issues relevant to neurological disorders.