Publications by authors named "E Stahlberg"
Article Synopsis
- Endometrial cancer (EC) is a growing health issue with rising incidence and mortality, and there is still a lack of understanding of its molecular mechanisms.
- This study analyzed data from The Cancer Genome Atlas (TCGA-UCEC) to identify gene co-expression patterns and potential biomarkers for EC using various analytical methods.
- The results highlighted a specific gene module (Green module M5) linked to patient survival and identified key genes involved in crucial processes like cell cycle regulation and signaling, suggesting new avenues for prognosis and treatment strategies.
Article Synopsis
- The study focuses on identifying and characterizing structural variants (SVs) in cancer genomes, which are vital for cancer diagnostics and personalized medicine.
- A consensus SV call set was created from a breast cancer cell line and matched normal control, discovering 1788 SVs including deletions, duplications, and translocations.
- The accuracy of the SV call set was validated using several independent methods, highlighting the strengths and weaknesses of different next-generation sequencing (NGS) technologies for detecting these variations.
We are rapidly approaching a future in which cancer patient digital twins will reach their potential to predict cancer prevention, diagnosis, and treatment in individual patients. This will be realized based on advances in high performance computing, computational modeling, and an expanding repertoire of observational data across multiple scales and modalities. In 2020, the US National Cancer Institute, and the US Department of Energy, through a trans-disciplinary research community at the intersection of advanced computing and cancer research, initiated team science collaborative projects to explore the development and implementation of predictive Cancer Patient Digital Twins.
View Article and Find Full Text PDFPercutaneous Thrombectomy in Patients with Occlusions of the Aortoiliac Segment: A Case Series.
Cardiovasc Intervent Radiol
November 2022
Objective: Thrombectomy of the aortoiliac segment remains a challenge for surgical and endovascular revision. This study aimed to evaluate the concept of percutaneous thrombectomy in patients with aortoiliac segment occlusions.
Materials & Methods: Eighteen patients with aortoiliac occlusion who underwent percutaneous thrombectomy were retrospectively identified using the local picture archive and divided into the stent-graft (N = 10) and native vessels (N = 8) groups.
Background: Recent studies on the Endurant™ endografts mainly compared outcomes of the bimodular stent-graft to other manufacturer's endografts or reported results for cases outside manufacturer's instructions for use (IFU), while data on the experience of standard endovascular aortic repair (EVAR) of infrarenal abdominal aortic aneurysms (AAA) inside manufacturer's IFU comparing the bi- with the trimodular device is limited.
Methods: Inclusion criteria were: 1) infrarenal aneurysms (>50 mm diameter) treated by Endurant II (END II) or Endurant IIs (END IIs) stent-graft inside manufacturer's IFU; 2) available CTA with 1 mm reconstruction of the entire aorta prior to intervention. Endpoints comparing the devices included technical success, 30-day mortality, rate of complications (bleeding with conversion to open repair, stent-graft stenosis/occlusion, acute distal embolism, infection or postprocedural necessity of dialysis), endoleaks and reinterventions (5-year follow-up).