Publications by authors named "E St Lezin"
Harnessing the spatial and transcriptional regulation of monoterpenoid indole alkaloid metabolism in Alstonia scholaris leads to the identification of broad geissoschizine cyclase activities.
Plant Physiol Biochem
November 2024
Monoterpene indole alkaloids (MIAs) are valuable metabolites produced in numerous medicinal plants from the Apocynaceae family such as Alstonia scholaris, which synthesizes strictamine, a MIA displaying neuropharmacological properties of a potential importance. To get insights into the MIA metabolism in A. scholaris, we studied here both the spatial and transcriptional regulations of MIA genes by performing a robust transcriptomics analysis of the main plant organs, leaf epidermis but also by sequencing RNA from leaves transiently overexpressing the master transcriptional regulator MYC2.
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- Plant-specialized metabolism is a rich source of bioactive compounds, like monoterpene indole alkaloids (MIAs), known for their health benefits including anticancer and neuroactive properties.
- The types of MIAs, particularly pachysiphine derivatives, have promising medical applications but are found in very low quantities in certain plant species, and there is a lack of genomic data needed to enhance their production.
- This study presents the genome sequence of the toad tree (Tabernaemontana elegans) and identifies genes that can synthesize pachysiphine, leading to engineered MIAs in yeast, thus paving the way for better production of these valuable compounds for pharmaceutical use.
Natural products represent an inestimable source of valuable compounds for human health. Notably, those produced by plants remain challenging to access due to their low production. Potential shortages of plant-derived biopharmaceuticals caused by climate change or pandemics also regularly tense the market trends.
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