Synthesis and biological evaluation of potent benzoselenophene and heteroaromatic analogues of ()-1-(chloromethyl)-8-methoxy-2,3-dihydro-1-benzo[]indol-5-ol (-MCBI).

A diverse series of compounds (18a-x) were synthesized from ()-1-(chloromethyl)-8-methoxy-2,3-dihydro-1-benzo[]indol-5-ol (-MCBI) and benzoselenophene or heteroaromatic acids. These new compounds were evaluated for their cytotoxicity against the human gastric NCI-N87 and human ovarian SK-OV3 cancer cell lines. The incorporation of a methoxy substituent at the C-7 position of the -CBI unit enhances the cytotoxicity through its additional van der Waals interaction and gave a much higher potency than the corresponding -CBI-based analogues.

Isolation, synthesis and biological evaluation of phenylpropanoids from the rhizomes of Alpania galanga.

Bioactivity guided investigation of the DCM: MeOH (1:1) extract from the rhizomes of Alpinia galanga led to the isolation of phenylpropanoids (1-9) and their structures were established by 1H NMR, 13C NMR, IR a nd LC-MS/MS. Th ese compounds have b een evaluated for their in vitro anticanceractivity against the human cancer cell lines A549 (lung cancer), Colo-205 (colon cancer), A431 (skin cancer), NCI H460 (lung cancer), PC-3 (prostate cancer), and HT-29 (colon cancer). Compounds 4 and 9 showed potent anticancer activity (ranging from 1.

A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study.

The dried roots of Saussurea lappa, called costus roots, are used in the traditional system of medicine for the treatment of cancer. In our investigation for the anticancer constituents from the hexane extract of this plant, a new sesquiterpene (1) was isolated along with the known compounds costunolide (2), beta-cyclocostunolide (3), dihydro costunolide (4) and dehydro costuslactone (5). Their structures were established by the extensive spectroscopic analyses.