Publications by authors named "E Spera"

Objective: Atraumatic cerebrospinal fluid (CSF) rhinorrhea is uncommon in children and necessitates a multi-disciplinary evaluation for an etiology. Underlying osseous abnormality due to extensive or multifocal low flow vascular anomaly should be considered as a potential cause of spontaneous CSF leak. Treatment of multifocal low flow vascular anomalies may include medical and surgical approaches.

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Full-scale morphologically and biophysically realistic model networks, aiming at modeling multiple brain areas, provide an invaluable tool to make significant scientific advances from in-silico experiments on cognitive functions to digital twin implementations. Due to the current technical limitations of supercomputer systems in terms of computational power and memory requirements, these networks must be implemented using (at least) simplified neurons. A class of models which achieve a reasonable compromise between accuracy and computational efficiency is given by generalized leaky integrate-and fire models complemented by suitable initial and update conditions.

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The development of photoelectrode materials for efficient water splitting using solar energy is a crucial research topic for green hydrogen production. These materials need to be abundant, fabricated on a large scale, and at low cost. In this context, hematite is a promising material that has been widely studied.

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The brain's structural connectivity plays a fundamental role in determining how neuron networks generate, process, and transfer information within and between brain regions. The underlying mechanisms are extremely difficult to study experimentally and, in many cases, large-scale model networks are of great help. However, the implementation of these models relies on experimental findings that are often sparse and limited.

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Article Synopsis
  • The study aimed to determine how much Intubation-Associated Pneumonia (IAP) in ICUs could be prevented by analyzing patient risk factors and adherence to a European prevention bundle.
  • A survey included 1,840 ICU patients, revealing that 44% of IAP cases could potentially be prevented, with a subset analysis showing 40% prevention based on compliance with prevention guidelines.
  • While the results suggest a significant link between the number of preventive measures taken and lower IAP rates, the study’s design limits definitive conclusions about causation, and the small sample size in the compliance analysis was noted as a drawback.
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