Publications by authors named "E Spector"
Aim: To develop an automated computable phenotype (CP) algorithm for identifying diabetes cases in children and adolescents using electronic health records (EHRs) from the UF Health System.
Materials And Methods: The CP algorithm was iteratively derived based on structured data from EHRs (UF Health System 2012-2020). We randomly selected 536 presumed cases among individuals aged <18 years who had (1) glycated haemoglobin levels ≥ 6.
Article Synopsis
- - The study investigates whether the nasal mucosa serves as a drainage site for cerebrospinal fluid (CSF) in humans, particularly in the context of Alzheimer's disease (AD).
- - Using dynamic PET imaging with a specific radiotracer, researchers found a correlation between the drainage times of fluid in the brain and nasal pathways, particularly in subjects with amyloid presence.
- - Results suggest that the nasal pathway is linked to brain amyloid status and may contribute to understanding protein clearance in neurodegenerative diseases; further research is encouraged.
Routes of Drug Use Among Drug Overdose Deaths - United States, 2020-2022.
MMWR Morb Mortal Wkly Rep
February 2024
Preliminary reports indicate that more than 109,000 drug overdose deaths occurred in the United States in 2022; nearly 70% of these involved synthetic opioids other than methadone, primarily illegally manufactured fentanyl and fentanyl analogs (IMFs). Data from the western United States suggested a transition from injecting heroin to smoking IMFs. CDC analyzed data from the State Unintentional Drug Overdose Reporting System to describe trends in routes of drug use in 27 states and the District of Columbia among overdose deaths that occurred during January 2020-December 2022, overall and by region and drugs detected.
View Article and Find Full Text PDFMitochondria are the powerhouses of cells, responsible for energy production and regulation of cellular homeostasis. When mitochondrial function is impaired, a stress response termed mitochondrial unfolded protein response (UPRmt) is initiated to restore mitochondrial function. Since mitochondria and UPRmt are implicated in many diseases, it is important to understand UPRmt regulation.
View Article and Find Full Text PDFObjective: Having sufficient population coverage from the electronic health records (EHRs)-connected health system is essential for building a comprehensive EHR-based diabetes surveillance system. This study aimed to establish an EHR-based type 1 diabetes (T1D) surveillance system for children and adolescents across racial and ethnic groups by identifying the minimum population coverage from EHR-connected health systems to accurately estimate T1D prevalence.
Materials And Methods: We conducted a retrospective, cross-sectional analysis involving children and adolescents <20 years old identified from the OneFlorida+ Clinical Research Network (2018-2020).