Publications by authors named "E Solessio"
Article Synopsis
- Decision bias affects how accurately mice estimate their absolute visual threshold, which is often overlooked in psychophysical studies.
- A new one-alternative forced choice (1AFC) method was developed to measure this bias by training mice to detect a flash stimulus and analyzing their hit and false alarm rates.
- The results showed that using signal detection theory yielded bias-independent threshold estimates, while traditional methods showed strong correlations with decision bias, highlighting the effectiveness of signal detection for analyzing visual detection behavior in mice.
Signal integration of converging neural circuits is poorly understood. One example is in the retina where the integration of rod and cone signaling is responsible for the large dynamic range of vision. The relative contribution of rods versus cones is dictated by a complex function involving background light intensity and stimulus temporal frequency.
View Article and Find Full Text PDFHeteromeric Kv2.1/Kv8.2 channels are voltage-gated potassium channels localized to the photoreceptor inner segment.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how temporal contrast sensitivity (TCS), or the ability to detect changes in light intensity, is affected by the recovery speed of rod photoreceptors in mice with the P23H rhodopsin mutation, a common cause of retinitis pigmentosa (RP).
- Mice with this mutation show improved TCS compared to normal mice, even as they experience photoreceptor degeneration, particularly at higher light levels (≥1000 R*/rod/s) and specific flicker frequencies (3, 6, and 12 Hz).
- The enhanced TCS may serve as an early, non-invasive indicator of rod dysfunction in retinal degenerative diseases, supported by a comprehensive model of the underlying mechanisms.
Mouse photoreceptors are electrically coupled via gap junctions, but the relative importance of rod/rod, cone/cone, or rod/cone coupling is unknown. Furthermore, while connexin36 (Cx36) is expressed by cones, the identity of the rod connexin has been controversial. We report that FACS-sorted rods and cones both express but no other connexins.
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