Publications by authors named "E Snoeck"
Dopamine D2 receptor occupancy (D2RO) significantly influences the clinical effectiveness and safety of many antipsychotic drugs. Maintaining a D2RO range of 65%-80% provides the best antipsychotic effects while minimizing adverse reactions. Data from a Phase III trial were used to establish an exposure-response relationship for monthly intramuscular Risperidone ISM (75 and 100 mg) or placebo administered to adults with schizophrenia.
View Article and Find Full Text PDFAims: The aims of this study were to develop a population pharmacokinetic (PK) model for risperidone ISM® and to investigate the relationships between active moiety exposure, as described by apparent clearance (CL), and several covariates using all data from five clinical studies.
Methods: A population PK model was developed using active moiety concentrations from a study in healthy volunteers and two studies in patients with schizophrenia. Data from a comparative bioavailability study in medically stable patients and a Phase III study in patients with acute exacerbation of schizophrenia were then incorporated, using empirical Bayesian feedback and model refinement in NONMEM.
Article Synopsis
- The MnAlC alloy, which doesn't contain rare earth materials, is being recognized as a promising and affordable option for permanent magnets due to its high anisotropy field, saturation magnetization, and Curie temperature.
- A simple fabrication method was developed to produce a bulk -MnAlC magnet, utilizing electric arc-melting and a two-step heat treatment to achieve a pure -MnAlC ingot.
- The resulting -MnAlC showed improved magnetic properties with a remanent magnetization of 42 Am/kg and a maximum energy product of 6.07 kJ/m, surpassing previous results and demonstrating high-quality ferromagnetic behavior.
Article Synopsis
- Lithographically defined nanomagnet arrays, like artificial spin ice (ASI), are useful for applications in probabilistic computing and magnonics due to their unique magnetic dynamics and configurations.
- ASI arrays experience geometric frustration, leading to the formation of topologically protected magnetic charges called monopoles, which require careful manipulation to avoid affecting neighboring charges.
- By introducing ferromagnetic defects in the ASI lattice, the research allows for the controlled creation and movement of monopoles, paving the way for advanced applications like reconfigurable nanomagnonic devices.
Article Synopsis
- - Magnetotactic bacteria (MTB) create magnetic nanoparticles that serve as unique biosignatures in geological samples, although some fossilized patterns show conflicting magnetic signatures from different origins.
- - By using micromagnetic simulations and studying mutant MTB, this research reveals that the observed magnetofossil fingerprints result from a mix of single-stranded and multi-stranded magnetosome chains, emphasizing the importance of their strong uniaxial anisotropy for differentiating them from other natural magnetite particles.
- - The findings help distinguish MTB lineages based on their chain and magnetosome shapes, which aids in tracking the evolution of ancient biomineralizing organisms and enhances the accuracy of environmental reconstructions from sediment records.