Publications by authors named "E Sitterle"
Unlabelled: Intestinal microsporidiosis caused by is an opportunistic infection that especially affects solid organ transplant (SOT) recipients. Management revolves around tapering the immunosuppressive regimen and/or using a specific anti-microsporidia treatment, but only fumagillin has demonstrated efficacy for treatment of this infection. Since fumagillin has been commercially discontinued, nitazoxanide is increasingly being used in this indication.
View Article and Find Full Text PDFUnlabelled: Mucormycosis is a severe and emerging invasive fungal infection associated with high mortality rates. Early diagnosis is crucial for initiating specific antifungal treatment, with molecular tools currently representing the most efficient diagnostic approach. Presently, a standardized in-house real-time PCR method is widely employed for diagnosing mucormycosis.
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- Deep cutaneous mycoses (DCMs) are rare infections that predominantly affect kidney transplant recipients, with a noted increase in incidence potentially linked to a growing population of organ transplant patients.
- A study reviewed 20 cases over 12 years, revealing lesions mainly on limbs as single nodular formations with positive direct mycological examinations in 85% of cases, identifying 13 different fungal species.
- Treatment involving antifungals was common, and the presence of (1-3) beta-D-glucan antigen in serum proved to be a reliable diagnostic tool, emphasizing the need for tailored antifungal therapy based on the specific fungal species identified.
Background: Metagenomic next-generation sequencing (mNGS) allows untargeted identification of a broad range of pathogens, including rare or novel microorganisms. Despite the recognition of mNGS as a valuable diagnostic tool for infections, the most relevant indications for this innovative strategy remain poorly defined. We aimed to assess the determinants of positivity and clinical utility of mNGS.
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