Publications by authors named "E Shor"
Anastomotic leakage (AL) is one of the most devastating complications after colorectal surgery. The verification of the adequate perfusion of the anastomosis is essential to ensuring anastomosis integrity following colonic resections. This study aimed to evaluate the efficacy of measuring the electrical activity of the colonic muscularis externa at an anastomosis site for perfusion analysis following colorectal surgery.
View Article and Find Full Text PDFDrug-resistant microbes typically carry mutations in genes involved in critical cellular functions and may therefore be less fit under drug-free conditions than susceptible strains. Candida glabrata is a prevalent opportunistic yeast pathogen with a high rate of fluconazole resistance (FLZR), echinocandin resistance (ECR), and multidrug resistance (MDR) relative to other Candida. However, the fitness of C.
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- * Resistance mutations in the β-glucan synthase genes (FKS1 and FKS2) are linked to treatment failures, but other unidentified factors influence echinocandin susceptibility.
- * Research on C. glabrata in mice treated with caspofungin revealed rapid genetic changes, including mutations in the FEN1 gene that increase resistance by affecting phytosphingosine levels, which also occurs in clinical strains.
Article Synopsis
- Fungal plasma membrane proteins are crucial targets for antifungal treatments, but their structures and distributions are not well understood.
- This study uses techniques like cryo-electron tomography and live cell imaging to investigate the organization of essential membrane proteins, GS and Pma1, finding they are unevenly spread in the plasma membrane.
- The research reveals that the antifungal drug caspofungin alters the distribution of these proteins, suggesting a new model for how echinocandin drugs work by affecting the plasma membrane environment of fungal cells.
Floral scent emission of petunia flowers is regulated by light conditions, circadian rhythms, ambient temperature and the phytohormones GA and ethylene, but the mechanisms underlying sensitivity to these factors remain obscure. PHYTOCHROME INTERACTING FACTORs (PIFs) have been well studied as components of the regulatory machinery for numerous physiological processes. Acting redundantly, they serve as transmitters of light, circadian, metabolic, thermal and hormonal signals.
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