Prognostic significance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer.

Background: To investigate the prognostic importance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer (NSCLC).

Patients And Methods: Using a prospective design, 118 consecutive participants with histologically confirmed metastatic (inoperable) NSCLC and Eastern Cooperative Oncology group (ECOG) 0-3 completed a six-minute walk test to assess functional capacity and questionnaire that assessed self-reported exercise behavior. Cox proportional models were used to estimate the risk of all-cause mortality according to six-minute walk distance (6MWD) (<358.

Central conduction time in childhood autism.

To investigate the integrity of the brain-stem in 20 mentally handicapped children who met the Rutter criteria for autism, brain-stem auditory evoked potentials were obtained for a range of stimulus intensities. Central conduction times (CCTs) were calculated for the Wave I-Wave V interval of the brain-stem potentials. In children under 14 years of age CCTs were normal.

Peripheral corneal oedema following cataract extraction (Brown-McLean syndrome).

We describe the clinical features of 21 eyes of 15 patients who developed peripheral bullous corneal oedema following cataract extraction. The peripheral oedema was asymptomatic in all cases and was only noted at a review examination. Although the onset of the peripheral oedema was probably delayed for several years after surgery, it was not documented to progress in any patient or to involve the central cornea.

On the morphology of cells of posterior cornea in the iridocorneal endothelial syndrome.

The iridocorneal endothelial (ICE) syndrome is potentially a blinding condition as a result of glaucoma and/or corneal decompensation. The basic pathology seems to be in the corneal endothelium, which many studies confirm takes on a characteristic slit lamp appearance of hammered silver and image reversal with the specular microscope. The origin and morphology of the abnormal cells are unknown.

The posterior corneal surface in posterior polymorphous dystrophy: a specular microscopical study.

Forty-eight cases of posterior polymorphous dystrophy (PPD), diagnosed on the presence of classic vesicles at the level of Descemet's membrane, were studied with the specular microscope. Vesicles alone occurred in 42% and were present in conjunction with PPD bands in 48% and a diffuse abnormality of Descemet's membrane in 10%. It was notable that none of the cases showed ocular abnormalities other than those of the cornea.