[Segregation analysis of some anthroposcopic characteristics. II. Age dependence and signs with three phenotypic variants].

Results of genetic analysis of three anthroposcopic traits, performed on a sample of pedigrees from a Kyrgyz population, are presented. The segregation analysis method used allows analysis of pedigrees of arbitrary structure with account of age dependence of genotype penetrances. The method involves analysis of not only binary traits, but also of traits with three phenotypic.

[Segregation analysis of certain anthroposcopic characteristics. I. Alternative signs with penetration independent of age].

Genetic analysis of a number of anthroposcopic traits was attempted using a sample of pedigrees from the Kirgiz population. We used methods of binary trait segregation analysis, which allowed us to analyze pedigrees of arbitrary structure. The genetic model applied was based on the monogenic diallelic mode of inheritance with arbitrary genotype penetrances and allowed for different phenotypic expressions of a genotype in males and females.

[The characteristics of the lipid-hormonal interrelations in young men with a history of myocardial infarct (based on family registry data in Novosibirsk and Bishkek)].

Altogether 226 male probands who suffered large-focal or transmural myocardial infarction (MI) before reaching 50 years were examined in Novosibirsk and Bishkek in one stage according to the unified program. In Novosibirsk all the probands were Russians whereas in Bishkek 75 probands were Kirghizs and 71 were Russians. The probands were examined within a period of 1 to 3 years after MI.

[Feasibility of monogenic control of blood cholesterol content for the Kirghiz population].

The samples presented by 67 pedigrees ascertained from the Kirghiz population via proband having an early myocardial infarction were analysed for ischemic heart disease. It is shown that these pathologies are not accompanied by high increase in the cholesterol level, as is usual for the European populations. Segregation analysis of the cholesterol level was performed and a possibility of monogenic control of this trait was demonstrated.

[The prevalence of the main risk factors among probands who have had a myocardial infarct at a young age and among their relatives (based on family registry data in Bishkek and Novosibirsk)].

Macrofocal or transmural myocardial infarction at the age under 50 in probands served the criterion for selection of 136 families in Bishkek and Novosibirsk (66 Kirghiz and 70 Russian families, respectively). Main risk factors in probands and their families were determined according to WHO methodological recommendations. Essential hypertension was more prevalent in probands and their families in Bishkek, while hypercholesterolemia was more common in Novosibirsk families.