[Diagnostic and treatment strategy for patients with the first episode of primary spontaneous pneumothorax].

A retrospective analysis of 198 patients (164 men and 28 women) with the first episode of primary spontaneous pneumothorax (PSP) was made. All the patients underwent diagnostic thoracoscopy (DT) under local anesthesia before insertion of a chest tube. For 115 patients the chest tube thoracoscopy was the only treatment procedure (group I) and 77 patients underwent video-assisted thoracoscopic (VATS) wedge (atypical) resection and pleurectomy (group II).

[Ultrastructural study of the action of cyclosporine on cells of the fungus Aspergillus niger].

Electron microscopy of the ultrastructure of the Aspergillus niger cells exposed to cyclosporine in acute experiments revealed changes in the mycelium morphology, hyphae growth and cell structure in the organism sensitive to cyclosporine. The analysis of the changes showed that the primary target of the cyclosporine action was the cell cytoplasmic membrane. The changes in the matrix of the cytoplasmic membrane, mitochondria and cell wall were likely mediated or secondary after the impairment of the cytoplasmic membrane.

[Cyclosporin A and the permeability of the cytoplasmic membrane in Aspergillus niger].

Cyclosporine A was shown to impair selective permeability of cytoplasmic membranes in Aspergillus niger thus inducing leakage of low molecular components of the intracellular fond from the cells. In this respect lyposomal cyclosporine had a more pronounced action than the free form. Cyclosporine was compared with amphotericin B and the latter in the free and lyposomal forms demonstrated a higher effect on the cell membranes of Asp.