Publications by authors named "E Sgarbi"

In this work, we propose a possible correlation between carbohydrate content in hazelnut pollen (wild type) and viability/germinability, also in a perspective of adaptation to climate variability. Samples from four different cultivation fields in Italy showed values of pollen viability characterized by high levels, ranging between 77.3 and 98.

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Article Synopsis
  • The study utilizes fluorescence lifetime imaging microscopy (FLIM) to investigate how nanoencapsulated liposomal all-trans retinoic acid (ATRA) interacts with liposomal membranes, utilizing ATRA's natural fluorescence for signal detection.
  • The method is validated through additional techniques like small-angle X-ray scattering (SAXS) and nano-differential scanning calorimetry (NanoDSC), confirming ATRA's location and impact on membrane structure.
  • Results highlight the effectiveness of Phasor-FLIM in analyzing the nanoscale organization of fluorescent drugs, emphasizing the significance of advanced imaging in enhancing drug delivery systems.
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Thiazolidinediones (TZDs) are potent PPARγ agonists that have been shown to attenuate alveolar simplification after prolonged hyperoxia in term rodent models of bronchopulmonary dysplasia. However, the pulmonary outcomes of postnatal TZDs have not been investigated in preterm animal models. Here, we first investigated the PPARγ selectivity, epithelial permeability, and lung tissue binding of three types of TZDs in vitro (rosiglitazone (RGZ), pioglitazone, and DRF-2546), followed by an in vivo study in preterm rabbits exposed to hyperoxia (95% oxygen) to investigate the pharmacokinetics and the pulmonary outcomes of daily RGZ administration.

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Pulmonary surfactant is a complex lipoprotein mixture secreted into the alveolar lumen by type 2 pneumocytes, which is composed by tens of different lipids (approximately 90% of its entire mass) and surfactant proteins (approximately 10% of the mass). It is crucially involved in maintaining lung homeostasis by reducing the values of alveolar liquid surface tension close to zero at end-expiration, thereby avoiding the alveolar collapse, and assembling a chemical and physical barrier against inhaled pathogens. A deficient amount of surfactant or its functional inactivation is directly linked to a wide range of lung pathologies, including the neonatal respiratory distress syndrome.

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A method of liquid chromatography coupled with tandem mass spectrometry was developed and validated for the determination of free soluble phenolic compounds in eight ancient varieties of wheat ( Triticum sp. pl.): Autonomia, Gentil rosso, Inallettabile, Leone aristato, Mentana, Poulard di Ciano, Risciola, and Terminillo.

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