Publications by authors named "E Serasli"
Despite advances, few therapeutics have shown efficacy in severe coronavirus disease 2019 (COVID-19). In a different context, virus-specific T cells have proven safe and effective. We conducted a randomized (2:1), open-label, phase 1/2 trial to evaluate the safety and efficacy of off-the-shelf, partially human leukocyte antigen (HLA)-matched, convalescent donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells (CoV-2-STs) in combination with standard of care (SoC) in patients with severe COVID-19 compared to SoC during Delta variant predominance.
View Article and Find Full Text PDFArticle Synopsis
- Valproic acid is often used to treat seizure disorders and manic episodes but has been linked to valproate-induced pleural effusion, a condition with an unclear mechanism.
- The study aimed to analyze cases of pleural effusion related to valproate use, categorizing them by clinical features and types of immune response.
- The majority of identified cases (60.7%) involved exudative eosinophilic pleural effusion, indicating a possible hypersensitivity reaction or inflammation caused by the medication.
Article Synopsis
- - The Stewart-Figge acid-base model is complex, so researchers created a simpler bedside version using mid-reference concentrations for calcium and magnesium and setting pH to 7.4.
- - The new model features adjusted values for strong ion difference ([SIDa, adj]) and a "bicarbonate gap" ([BICgap]), with high accuracy for diagnosing various acid-base disorders in patients with respiratory issues.
- - The study showed strong correlations and predictive accuracies for diagnosing conditions like strong ion acidosis and unmeasured ion acidosis using the new model, which performs well compared to traditional methods.
Background: Respiratory dysfunction often persists in post intensive care unit (ICU) patients and intermediate care facilities have been established to ensure the continuous of appropriate care.
Methods: The data of patients with difficult weaning from mechanical ventilation admitted to a respiratory intermediate unit (RIU) attached to a pulmonary department of a General Hospital, were retrospectively analyzed. Clinical characteristics, weaning from mechanical ventilation and tracheostomy, ICU readmission and RIU mortality were examined over a period of 18 years (1993- 2010) that was randomly divided into three six-year-periods.