Publications by authors named "E Senthil Anand"
Article Synopsis
- An adolescent female with benzodiazepine-resistant malignant catatonia initially did not respond to single-stimulation electroconvulsive therapy (ECT) but showed improvement with multiple monitored ECT (mmECT).
- The use of mmECT was justified due to her life-threatening condition and the brief seizures experienced during single-stimulation ECT, supporting its consideration for intractable cases.
- After treatment, the patient's condition significantly improved, as seen in her decreased Catatonia Rating Scale score, and she successfully returned to school without needing ongoing ECT at a 2-year follow-up.
Background: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.
Methods: Acoustophoresis uses an ultrasonic standing wave field to separate cells based on biomechanical properties (size, density, and compressibility) resulting in inherently label-free and epitope-independent cell enrichment.