Publications by authors named "E Seilles"
Neoplasms involving plasmacytoid Dendritic Cells (pDCs) include Blastic pDC Neoplasms (BPDCN) and other pDC proliferations, where pDCs are associated with myeloid malignancies: most frequently Chronic MyeloMonocytic Leukemia (CMML) but also Acute Myeloid Leukemia (AML), hereafter named pDC-AML. We aimed to determine the reactive or neoplastic origin of pDCs in pDC-AML, and their link with the CD34+ blasts, monocytes or conventional DCs (cDCs) associated in the same sample, by phenotypic and molecular analyses (targeted NGS, 70 genes). We compared 15 pDC-AML at diagnosis with 21 BPDCN and 11 normal pDCs from healthy donors.
View Article and Find Full Text PDFBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia for which we developed a nationwide network to collect data from new cases diagnosed in France. In a retrospective, observational study of 86 patients (2000-2013), we described clinical and biological data focusing on morphologies and immunophenotype. We found expression of markers associated with plasmacytoid dendritic cell origin (HLA-DRhigh, CD303+, CD304+, and cTCL1+) plus CD4 and CD56 and frequent expression of isolated markers from the myeloid, B-, and T-lymphoid lineages, whereas specific markers (myeloperoxidase, CD14, cCD3, CD19, and cCD22) were not expressed.
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- Nocardia infections pose a significant threat to immunocompromised patients, particularly after allogeneic hematopoietic cell transplantation (AHCT), where the reconstitution of the immune system, especially CD4 T-cells, is crucial for recovery.
- This study analyzed 15 cases of nocardiosis post-AHCT and assessed their immune status compared to a control group with similar transplantation characteristics, focusing on the counts of various lymphocyte populations.
- The findings revealed that patients with nocardiosis had significantly lower counts of circulating lymphocytes, CD4 T-cells, and naïve CD4 T-cells, indicating impaired immune recovery in these patients compared to the control cohort.