Publications by authors named "E Schwier"
Article Synopsis
- Sepsis involves intricate immune responses, and the protein GILZ is crucial in balancing inflammation and anti-inflammation; this study looks at how different forms of GILZ transcripts can be used to categorize patients and improve treatment effectiveness with glucocorticoids.
- The research involved analyzing RNA from blood samples of 121 sepsis patients to measure GILZ transcript variants and to see their relation to mortality rates and glucocorticoid responses.
- Findings indicate that high levels of GILZ transcript variant 1 (GILZ TV 1) significantly correlate with increased 30-day mortality in sepsis patients, especially the first eight days after onset, suggesting it can help identify patients who may not
The variability in mortality in sepsis could be a consequence of genetic variability. The glucocorticoid system and the intermediate TSC22D3 gene product-glucocorticoid-induced leucine zipper-are clinically relevant in sepsis, which is why this study aimed to clarify whether TSC22D3 gene polymorphisms contribute to the variance in sepsis mortality. Blood samples for DNA extraction were obtained from 455 patients with a sepsis diagnosis according to the Sepsis-III criteria and from 73 control subjects.
View Article and Find Full Text PDFPurpose: Liver function of intensive care patients is routinely monitored by static blood pathology. For specific indications, liver specific cytochrome activity may be measured by the commercially available maximum liver function capacity (LiMAx) test via quantification of the cytochrome P450 1A2 (CYP1A2) dependent C-methacetin metabolism. Sedation with the volatile anesthetic isoflurane was suspected to abrogate the correlation of LiMAx test with global liver function.
View Article and Find Full Text PDFSepsis is a common life-threatening disease caused by dysregulated immune response and metabolic acidosis which lead to organ failure. An abnormal expression of aquaporins plays an important role in organ failure. Additionally, genetic variants in aquaporins impact on the outcome in sepsis.
View Article and Find Full Text PDFSepsis involves an immunological systemic response to a microbial pathogenic insult, leading to a cascade of interconnected biochemical, cellular, and organ-organ interaction networks. Potential drug targets can depict aquaporins, as they are involved in immunological processes. In immune cells, AQP3 and AQP9 are of special interest.
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