An integrated molecular risk score early in life for subsequent childhood asthma risk.

Background: Numerous children present with early wheeze symptoms, yet solely a subgroup develops childhood asthma. Early identification of children at risk is key for clinical monitoring, timely patient-tailored treatment, and preventing chronic, severe sequelae. For early prediction of childhood asthma, we aimed to define an integrated risk score combining established risk factors with genome-wide molecular markers at birth, complemented by subsequent clinical symptoms/diagnoses (wheezing, atopic dermatitis, food allergy).

Trajectories of cough without a cold in early childhood and associations with atopic diseases.

Background: Although children can frequently experience a cough that affects their quality of life, few epidemiological studies have explored cough without a cold during childhood.

Objectives: The objective of the study was to describe the latent class trajectories of cough from one to 10 years old and analyse their association with wheezing, atopy and allergic diseases.

Methods: Questions about cough, wheeze and allergic diseases were asked at 1, 1.

Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development.

Background: An important window of opportunity for early-life exposures has been proposed for the development of atopic eczema and asthma.

Objective: However, it is unknown whether hay fever with a peak incidence around late school age to adolescence is similarly determined very early in life.

Methods: In the Protection against Allergy-Study in Rural Environments (PASTURE) birth cohort potentially relevant exposures such as farm milk consumption and exposure to animal sheds were assessed at multiple time points from infancy to age 10.

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers.

In murine models, microbial exposures induce protection from experimental allergic asthma through innate immunity. Our aim was to assess the association of early life innate immunity with the development of asthma in children at risk. In the PASTURE farm birth cohort, innate T-helper cell type 2 (Th2), Th1, and Th17 cytokine expression at age 1 year was measured after stimulation of peripheral blood mononuclear cells with LPS in  = 445 children.

Inverse associations between food diversity in the second year of life and allergic diseases.

Background: The influence of diet in early childhood on later allergic diseases is currently a highly debated research topic. We and others have suggested that an increased diet diversity in the first year of life has a protective effect on the development of allergic diseases.

Objective: This follow-up study aimed to investigate associations between diet in the second year of life and later allergic diseases.