Publications by authors named "E Schimmel"

Purpose: Female Hodgkin lymphoma (HL) survivors treated with chest radiotherapy (RT) at a young age have a strongly increased risk of breast cancer (BC). Studies in childhood cancer survivors have shown that doxorubicin exposure may also increase BC risk. Although doxorubicin is the cornerstone of HL chemotherapy, the association between doxorubicin and BC risk has not been examined in HL survivors treated at adult ages.

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Article Synopsis
  • The study highlights that five-year survivors of diffuse large B-cell lymphoma (DLBCL) are at a higher risk of developing subsequent malignant neoplasms (SMNs), particularly among younger patients and those treated with higher doses of certain chemotherapy drugs.
  • After a median follow-up of 13.8 years, 321 out of 2373 survivors developed SMNs, with significant increases noted for lung and gastrointestinal cancers.
  • The research indicates that treatment including rituximab may lower the risk of certain cancers, underscoring the importance of long-term monitoring of DLBCL survivors and the need for further studies to assess risks associated with newer treatments.
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Background: Myasthenic crisis (MC) requiring mechanical ventilation (MV) is a rare and serious complication of myasthenia gravis. Here we analyzed the frequency of performed tracheostomies, risk factors correlating with a tracheostomy, as well as the impact of an early tracheostomy on ventilation time and ICU length of stay (LOS) in MC.

Methods: Retrospective chart review on patients treated for MC in 12 German neurological departments between 2006 and 2015 to assess demographic/diagnostic data, rates and timing of tracheostomy and outcome.

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Objective: To determine demographic characteristics, clinical features, treatment regimens, and outcome of myasthenic crisis (MC) requiring mechanical ventilation (MV).

Methods: Analysis of patients who presented with MC between 2006 and 2015 in a German multicenter retrospective study.

Results: We identified 250 cases in 12 participating centers.

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Background: Health and wellbeing initiatives vary in effectiveness due to programme design and offerings. The Partnership for Prevention programme expands access to up to 40 evidence-based clinical preventive services for all employees and eligible family members as part of a unique global health initiative.

Methods: Using a published RAND Europe model developed for the company, country-level return on investment was estimated over a five-year timeframe using programme utilisation data.

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