Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation.

MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al. report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (FASN), resulting in inhibition of tumor growth.

A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation.

Metastasis is a multistep process in which cells must detach, migrate/invade local structures, intravasate, circulate, extravasate, and colonize. A full understanding of the complexity of this process has been limited by the lack of ability to study these steps in isolation with detailed molecular analyses. Leveraging a comparative oncology approach, we injected canine osteosarcoma cells into the circulation of transgenic zebrafish with fluorescent blood vessels in a biologically dynamic metastasis extravasation model.

Consciousness after split-brain surgery: The recent challenge to the classical picture.

In a recent series of experiments, Pinto and colleagues found that the split-brain patient D.D.C.

A safe and comparable alternative to BIPP packing following tympanoplasty for tympanic membrane perforation.

Purpose: To compare two post-operative ear packing methods following tympanoplasty for tympanic membrane perforation.

Methods: A prospective study of patients undergoing tympanoplasty for tympanic membrane perforation over a 2-year period was undertaken across two district general hospitals. Data, including demographics, pre-operative ear state, and graft type used for repair were recorded.