Publications by authors named "E Schalk"
Introduction: Men are generally more susceptible to bacterial infections than women. Central venous catheters (CVCs), often used to administer systemic treatment in patients with cancer, are an important source of infection. However, little is known about sex-specific differences of CVC-related bloodstream infections (CRBSIs) in patients with cancer.
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- Lautropia mirabilis is a Gram-negative bacterium associated with respiratory infections in patients with weakened immune systems, such as those with HIV or cystic fibrosis; however, its pathogenicity is not well understood due to limited cases.
- A 39-year-old female with common variable immunodeficiency (CVID) experienced sepsis caused by L. mirabilis, which was identified through blood cultures and effectively treated with meropenem.
- Whole genome sequencing of L. mirabilis showed genes that aid in invading host cells and surviving inside them, underscoring the need to recognize its potential danger beyond respiratory infections in immunocompromised individuals.
Comparative effectiveness of vancomycin and metronidazole on event-free survival after initial infection in patients with Clostridioides difficile-a German multicentre cohort study.
Clin Microbiol Infect
November 2024
Objectives: The objective of this study is to examine the comparative effectiveness of vancomycin and metronidazole in a confirmatory analysis of event-free survival (EFS) after initial infection in patients with Clostridioides difficile from a German multicentre cohort study.
Methods: The IBIS multicentre cohort enrolled patients with an index episode of C. difficile infection between August 2017 and September 2020.
Article Synopsis
- Scientists studied a sensor called STING that helps the body respond to stress and viruses, even when there isn’t typical DNA present.* -
- They found that a special stress response in cells called the unfolded protein response (UPR) can activate STING and help create a certain type of DNA that triggers defense responses.* -
- They discovered that two specific pathways in the UPR, called IRE1 and PERK, play important roles in releasing this DNA and activating immune responses against viruses.*