Publications by authors named "E Saus"
Hybridisation is a source of genetic diversity, can drive adaptation to new niches and has been found to be a frequent event in lineages harbouring pathogenic fungi. However, little is known about the genomic implications of hybridisation nor its impact on pathogenicity-related traits. A common limitation for addressing these questions is the narrow representativity of sequenced genomes, mostly corresponding to strains isolated from infected patients.
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- * Genetic studies have identified issues with Notch signaling and inflammasome function in HS, while syndromic HS is linked to mutations in certain autoinflammatory syndromes like PAPA and PASH.
- * Research in proteomics and microbiome profiling highlights inflammatory pathways and a disturbed balance of bacteria in HS lesions, while metabolomic studies reveal imbalances in tryptophan and lipid metabolism, indicating potential bacterial involvement; however, establishing strong links across these
Article Synopsis
- - The study investigates the reliability of two sequencing methods, 16S rRNA gene and shotgun metagenomic sequencing, in profiling gut microbiota associated with colorectal cancer (CRC) using 156 stool samples from different patient groups.
- - Results indicate that 16S captures only part of the microbiota detected by shotgun, with notable differences in abundance, diversity, and taxonomic resolution due to varying reference databases.
- - Both techniques can reveal microbial signatures linked to CRC, but no clear superiority of one method over the other was established, suggesting they provide complementary insights into gut microbiota analysis.
Understanding the intricate roles of RNA molecules in virulence and host-pathogen interactions can provide valuable insights into combatting infections and improving human health. Although much progress has been achieved in understanding transcriptional regulation during host-pathogen interactions in diverse species, more is needed to know about the structure of pathogen RNAs. This is particularly true for fungal pathogens, including pathogenic yeasts of the genus, which are the leading cause of hospital-acquired fungal infections.
View Article and Find Full Text PDFColorectal cancer (CRC), the third most common cancer globally, has shown links to disturbed gut microbiota. While significant efforts have been made to establish a microbial signature indicative of CRC using shotgun metagenomic sequencing, the challenge lies in validating this signature with 16S ribosomal RNA (16S) gene sequencing. The primary obstacle is reconciling the differing outputs of these two methodologies, which often lead to divergent statistical models and conclusions.
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