Ultrasound arterial anomalies in patients exposed to nilotinib therapy for chronic myeloid leukemia.

Introduction: Patients exposed to nilotinib for chronic myeloid leukemia (CML) appear to be at risk of arterial complication. The prevalence and aspect of ultrasound asymptomatic arterial lesions are unknown.

Objective: To describe prevalence and characteristics of ultrasound arterial anomalies in patients treated with nilotinib for CML.

Evaluation of different approaches for confounding in nonrandomised observational data: a case-study of antipsychotics treatment.

Although randomised controlled trials are regarded as the gold standard for treatments efficacy, evidence from observational studies remains relevant. To address the problem of possible confounding in these studies, investigators must employ analysis methods that adjust for confounders and lead to an unbiased estimation of the treatment effect. In this paper, the authors describe two relevant statistical methods.

Plasmatic level of leukocyte-derived microparticles is associated with unstable plaque in asymptomatic patients with high-grade carotid stenosis.

Objectives: This study sought to analyze whether the plasmatic level of leukocyte-derived microparticles (LMP) is associated with unstable plaques in patients with high-grade carotid stenosis.

Background: Preventive carotid surgery in asymptomatic patients is currently debated given the improvement of medical therapy. Therefore, noninvasive biomarkers that can predict plaque instability are needed.

A prospective study of health care resource utilisation and selected costs of schizophrenia in France.

Background: Schizophrenia is among the most burdensome and costly illnesses worldwide. To estimate the cost of schizophrenia in France, a longitudinal study was carried out between 1998 and 2002. The main objective of this study was to describe and update the cost of schizophrenia in a longitudinal, representative sample of French patients.

Imprisonment, alcohol dependence and risk of delusional disorder: a cross-sectional study.

Background: Compared to the general population, an excess of psychotic illnesses, major depression and dependence disorders among prisoners has been reported. However, the impact of prison on detainees' psychopathology has rarely been studied.

Objective: To determine the mental disorders liable to develop or regress on entry into prison and over time.