Publications by authors named "E Sanchez-Islas"
Article Synopsis
- Nitric oxide is recognized as a key neurotransmitter in the olfactory and chemoreception systems of both invertebrates and vertebrates, indicating a long-evolved sensory detection mechanism.
- Research specifically highlights the role of nitric oxide in molluscs, particularly octopuses, affecting their sensory integration and motor responses.
- The study provides evidence of nitric oxide synthase present in neurons and fibers in Octopus maya, showing its anatomical localization in brain regions related to chemosensory processing.
Polychlorinated biphenyls (PCBs) are industrial pollutants that act as endocrine disruptors and alter thyroid function. However, it is still unclear whether PCBs can affect hypothalamic thyrotropin releasing hormone (Trh) mRNA expression through TH signaling disruption. As salt-loading dehydration induces tertiary hypothyroidism in the hypothalamic parvocellular paraventricular nuclei (paPVN), and perinatal exposure to Aroclor 1254 (A1254) disrupts the hydric balance in rats, we hypothesized that TRH synthesis could be altered during dehydration in TRH neurons that control the hypothalamic-pituitary-thyroid (HPT) axis activity in rats perinatally exposed to A1254.
View Article and Find Full Text PDFSex-dependent and -independent regulation of thyrotropin-releasing hormone expression in the hypothalamic dorsomedial nucleus by negative energy balance, exercise, and chronic stress.
Brain Res
December 2022
The dorsomedial nucleus of the hypothalamus (DMH) is part of the brain circuits that modulate organism responses to the circadian cycle, energy balance, and psychological stress. A large group of thyrotropin-releasing hormone (Trh) neurons is localized in the DMH; they comprise about one third of the DMH neurons that project to the lateral hypothalamus area (LH). We tested their response to various paradigms.
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- * Researchers used retrograde and anterograde tracing techniques in rats and found that TRH neurons projecting to the TMN mainly originate from the tuberal lateral hypothalamus (TuLH).
- * The findings suggest that TRH from TuLH could play a role in controlling food intake and energy balance by influencing histaminergic signaling in the TMN, potentially impacting homeostasis in rodents.
Polybrominated diphenyl ethers (PBDEs) are persistent environmental pollutants considered as neurotoxicants and endocrine disruptors with important biological effects ranging from alterations in growth, reproduction, and effects on the hypothalamus-pituitary-adrenal axis. The vasopressinergic (AVPergic) system is a known target for pentaBDEs mixture (DE-71) and the structurally similar chemicals, polychlorinated biphenyls. However, the potential adverse effects of mixtures containing octaBDE compounds, like DE-79, on the AVPergic system are still unknown.
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