Publications by authors named "E Sala Lozano"
Article Synopsis
- Easily extractable glomalin (EEG) is a type of soil organic matter mainly produced by mycorrhizal fungi, important for soil functions like aggregation and water repellence.
- This study used analytical pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) to analyze the molecular composition of EEG in Mediterranean soils affected by different vegetation and environmental conditions, including forest fires.
- A total of 139 compounds were identified, showing that EEG is rich in lipids and plant-derived materials, and while resilient to heat, it has a composition resembling humic acids rather than typical glycoproteins.
Aims: Drug export through ABC proteins hinders cancer response to chemotherapy. Here, we have evaluated the relevance of MRP3 (ABCC3) in cholangiocarcinoma (CCA) as a potential target to overcome drug resistance.
Methods: Gene expression was analyzed in silico using the TCGA-CHOL database and experimentally (mRNA and protein) in resected CCA tumors.
Article Synopsis
- * The review specifically highlights genes in the transportome, part of the resistome, that are responsible for drug uptake, focusing on several solute carrier (SLC) gene families.
- * Understanding the changes in these genes and their variants over time is crucial for advancing personalized medicine and tackling the development of more resistant and aggressive cancer cell clones.
Antisense oligonucleotides (ASOs) are promising therapeutics for treating various neurological disorders. However, ASOs are unable to readily cross the mammalian blood-brain barrier (BBB) and therefore need to be delivered intrathecally to the central nervous system (CNS). Here, we engineered a human transferrin receptor 1 (TfR1) binding molecule, the oligonucleotide transport vehicle (OTV), to transport a tool ASO across the BBB in human TfR knockin (TfR KI) mice and nonhuman primates.
View Article and Find Full Text PDFMetabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIV.
Int J Mol Sci
August 2024
Article Synopsis
- The study evaluated the effects of the efavirenz, emtricitabine, and tenofovir disoproxil fumarate (EFV/FTC/TDF) treatment on metabolic, mitochondrial, and inflammatory parameters in people with HIV compared to untreated individuals.
- Results showed that while treatment significantly improved viral outcomes, it also led to increased levels of glucose, cholesterol, and triglycerides, indicating metabolic changes.
- Despite these metabolic alterations, mitochondrial function was mostly preserved, with some recovery in mitochondrial DNA, and a reduction in inflammatory markers was observed following treatment, suggesting some overall benefit.