Publications by authors named "E Sakihara"
COVID-19 mRNA vaccines induce protective adaptive immunity against SARS-CoV-2 in most individuals, but there is wide variation in levels of vaccine-induced antibody and T-cell responses. However, the mechanisms underlying this inter-individual variation remain unclear. Here, using a systems biology approach based on multi-omics analyses of human blood and stool samples, we identified several factors that are associated with COVID-19 vaccine-induced adaptive immune responses.
View Article and Find Full Text PDFBackground: Vibrio vulnificus is typically present in seawater, fish, and shellfish, and is known to cause severe sepsis, particularly in patients with liver diseases such as cirrhosis. V. vulnificus is one of the most dangerous waterborne pathogens, and infection mainly occurs in western Japan during the summer, with an increased fatality rate.
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- A 67-year-old man with fever and low blood cell counts developed cardiogenic shock three days into his hospital stay, showing symptoms of chest pain and cardiac dysfunction.
- Doctors suspected severe fever with thrombocytopenia syndrome (SFTS) after he had a tick bite, confirming the diagnosis with a serum PCR test.
- An endomyocardial biopsy taken later showed signs of myocardial inflammation, making this the first reported case of acute myocarditis linked to SFTS.
Article Synopsis
- Surgical site infections (SSIs) and catheter-related bloodstream infections (CRBSIs) are rising due to ineffective disinfection practices with common antiseptics like chlorhexidine gluconate (CHG) and povidone-iodine (PVP-I).
- The scoping review aimed to fill the knowledge gap regarding the disinfection efficacy of a newer antiseptic, olanexidine gluconate (OLG), which was developed to combat bacteria resistant to CHG and PVP-I.
- While OLG demonstrates strong antibacterial effects, particularly against resistant strains, evidence supporting its effectiveness in preventing SSIs and CRBSIs in clinical settings remains limited, indicating a need for more comprehensive research.
Purpose: Many individuals with obstructive airway disease (OAD), including chronic obstructive pulmonary disease (COPD) and asthma, remain undiagnosed, despite the potential for reducing disease burden through early detection and treatment. OCEAN aimed to determine the prevalence of, and characteristics associated with, impaired lung function in a Japanese population, with the goal of improving strategies for early OAD detection.
Methods: OCEAN was an observational, cross-sectional study in sequentially recruited Japanese individuals ≥40 years of age undergoing routine health examinations.