Publications by authors named "E Sakakibara"
Objective: Cognitive behavioral therapy for insomnia (CBT-I) has demonstrated efficacy for both insomnia and depression. With a tenfold increase in expected participant numbers, we aimed to update the systematic review and meta-analysis of CBT-I for major depressive disorders (MDD).
Methods: Multiple databases were searched up to March 27th 2024 to include all randomized controlled trials examining CBT-I among adults with MDD.
Discrepancies in self-rated and observer-rated depression severity may underlie the basis for biological heterogeneity in depressive disorders and be an important predictor of outcomes and indicators to optimize intervention strategies. However, the neural mechanisms underlying this discrepancy have been understudied. This study aimed to examine the brain networks that represent the neural basis of the discrepancy between self-rated and observer-rated depression severity using resting-state functional MRI.
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- - Dual specificity protein phosphatase 6 (DUSP6) is important in regulating late-onset Alzheimer's disease (AD), with lower DUSP6 levels linked to worse dementia ratings in humans and decreased levels observed in a mouse model of the disease.
- - Researchers injected AAV5-DUSP6 into the brains of 5xFAD mice to increase DUSP6 expression and found that it improved memory deficits and reduced amyloid plaques in male mice but not in female mice, while also decreasing microglial activation in both sexes.
- - Although DUSP6 overexpression helped reduce neuroinflammation and activated microglia in both male and female mice, the improvement in memory was sex-dependent, indicating different underlying mechanisms
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- Near-infrared spectroscopy (NIRS) is a noninvasive method that measures brain blood oxygenation to understand neural activity.
- Researchers studied resting-state brain activity in 24 individuals with schizophrenia and 90 healthy controls, discovering higher functional connectivity in specific brain areas of schizophrenia patients.
- The findings link increased brain connectivity to the severity of negative symptoms and dosage of antipsychotic medication, indicating NIRS could have useful clinical applications.
The use of biological host-guest interactions, specifically the binding of hemoprotein to heme, has attracted significant research interest in the design of artificial protein assemblies. However, because of the inherent flexibility of the propionic acid group of heme, it is difficult to control the positioning and orientation of the protein unit and to construct well-ordered structures. Herein, we report a heme-substituted protein dimer composed of the native hemoprotein HasA, which accommodates a tetraphenylporphyrin bearing an additional metal coordination site.
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