Pulsed beam monitoring for electron FLASH.

Background: Safe implementation and translation of FLASH radiotherapy to the clinic requirehs development of beam monitoring devices capable of high temporal resolution with wide dynamic ranges. Ideal detectors should be able to monitor LINAC pulses, withstand high doses and dose rates, and provide information about the beam output, energy/range, and profile.

Purpose: Two novel detectors have been designed and tested for ultra-high dose-rate (UHDR) monitoring: a multilayer nano-structured 3-layer high-energy-current (HEC3) detector, and a segmented large area, 4-section flat (S4) detector with the goal of exploring their properties for a future combined design.

Toward a multi-layer micro-structured detector for high-energy electron radiotherapy.

Background: The use of electron beams has been rekindled by the advent of ultra-high-dose rate radiotherapy (FLASH) and very high energy electrons (VHEE). The need for development of novel technology for beam monitoring and dosimetry of such beams is of paramount importance prior to their clinical translation.

Purpose: In this work we explore the potential of a multi-layer nanoporous aerogel High-Energy-Current (HEC) detector as a dosimeter for electron beam.

X-ray Induced Electric Currents in Anodized TaO: Towards a Large-Area Thin-Film Sensor.

Purpose: We investigated the characteristics of radiation-induced current in nano-porous pellet and thin-film anodized tantalum exposed to kVp X-ray beams. We aim at developing a large area (≫cm) thin-film radiation sensor for medical, national security and space applications.

Methods: Large area (few cm) micro-thin Ta foils were anodized and coated with a counter electrode made of conductive polymer.

Investigating the Use of a Liquid Immunogenic Fiducial Eluter Biomaterial in Cervical Cancer Treatment.

Globally, cervical cancer is the fourth leading cancer among women and is dominant in resource-poor settings in its occurrence and mortality. This study focuses on developing liquid immunogenic fiducial eluter (LIFE) Biomaterial with components that include biodegradable polymers, nanoparticles, and an immunoadjuvant. LIFE Biomaterial is designed to provide image guidance during radiotherapy similar to clinically used liquid fiducials while enhancing therapeutic efficacy for advanced cervical cancer.

Radioactive source localization employing resistive electrode array (REA) detector.

In this feasibility study, we explore an application of a Resistive Electrode Array (REA) for localization of a radioactive point source. The inverse problem posed by multichannel REA detection is studied from mathematical perspective and involves the questions of the minimal configuration of the conductive leads that can achieve this goal. The basic configuration consists of a circularly shaped REA with four opposite electrical lead-pairs at its perimeter.