Publications by authors named "E Sag"
Article Synopsis
- - The study focuses on Familial Mediterranean Fever (FMF), an autoinflammatory disease characterized by the activation of the pyrin inflammasome, potentially leading to a specific type of cell death called pyroptosis.
- - Researchers analyzed plasma samples from 25 FMF patients, alongside 10 patients with PFAPA and 10 healthy controls, to investigate the cell-death mechanisms during FMF attacks and the attack-free period.
- - Findings revealed that levels of specific proteins (sFasL and granzyme A) were significantly elevated during FMF attacks but returned to normal when the patient was attack-free, indicating a distinct inflammatory response not seen in the PFAPA group.
Unlabelled: Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) are considered the same disease, but a common approach for diagnosis and management is still missing.
Methods: In May 2022, EULAR and PReS endorsed a proposal for a joint task force (TF) to develop recommendations for the diagnosis and management of sJIA and AOSD. The TF agreed during a first meeting to address four topics: similarity between sJIA and AOSD, diagnostic biomarkers, therapeutic targets and strategies and complications including macrophage activation syndrome (MAS).
Objectives: Juvenile Idiopathic Arthritis (JIA) is the most common rheumatic disease of childhood; the pathogenesis is associated with T cell activation. T cell activation can be counter-balanced by signals generated by inhibitory receptors (IRs) such as CTLA-4, PD-1, LAG-3, and TIM-3. Here, we identify the role of IRs in the pathogenesis of different JIA subtypes.
View Article and Find Full Text PDFObjective: We aimed to investigate the presence of monogenic causes of systemic lupus erythematosus (SLE) in our early-onset SLE patients.
Methods: Fifteen pediatric SLE cases who had early disease onset (≤6 years) were enrolled in this study. All patients fulfilled the Systemic Lupus International Collaborating Clinics (SLICC) criteria.