Publications by authors named "E SIMONSON"
Aim: To evaluate the pharmacokinetics and efficacy of a novel somatostatin receptor 2 antagonist, ZT-01, to stimulate glucagon release in rats with type 1 diabetes (T1D).
Methods: The pharmacokinetics of ZT-01 and PRL-2903 were assessed following intraperitoneal or subcutaneous dosing at 10 mg/kg. We compared the efficacy of ZT-01 with PRL-2903 to prevent hypoglycaemia during an insulin bolus challenge and under hypoglycaemic clamp conditions.
Background: Endogenous fibrinolytic activation contributes to coagulopathy and mortality after trauma. Administering tranexamic acid (TXA), an antifibrinolytic agent, is one strategy to reduce bleeding; however, it must be given soon after injury to be effective and minimize adverse effects. Administering TXA topically to a wound site would decrease the time to treatment and could enable both local and systemic delivery if a suitable formulation existed to deliver the drug deep into wounds adequately.
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- Hemorrhage is a major cause of preventable death in trauma, particularly from hard-to-control junctional bleeding; current treatment involves a 3-minute compression with QuikClot Combat Gauze.
- Researchers developed a new dressing using calcium carbonate microparticles that can move against flowing blood, loaded with thrombin and tranexamic acid, and tested its effectiveness in a pig model of severe hemorrhage.
- The self-propelling microparticles (PTG) led to significantly higher 3-hour survival rates (100%) compared to traditional gauze (37.5%) and a non-propelling version (25%), while also showing better indicators of hemorrhagic shock without the need for compression.
Article Synopsis
- - The study investigates the role of the CXCL12/CXCR4 signaling pathway in pulmonary and hepatic fibrosis, particularly focusing on how this pathway affects collagen production in these conditions.
- - AMD070, a CXCL12/CXCR4 inhibitor, was tested for its effectiveness in treating fibrosis in mice but showed little impact on collagen deposition despite increasing leukocyte mobilization.
- - The findings suggest that while CXCL12/CXCR4 signaling may help improve survival in pulmonary injury, it is not a valuable target for reducing fibrosis itself.