Publications by authors named "E S Steinberg"
Checkpoint inhibitors targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) have revolutionized cancer therapy across many indications including urothelial carcinoma (UC). Because many patients do not benefit, a better understanding of the molecular mechanisms underlying response and resistance is needed to improve outcomes. We profiled tumors from 2,803 UC patients from four late-stage randomized clinical trials evaluating the PD-L1 inhibitor atezolizumab by RNA sequencing (RNA-seq), a targeted DNA panel, immunohistochemistry, and digital pathology.
View Article and Find Full Text PDFVarious stressors contribute to veterinary students' stress levels. According to the medical education literature, students' stress seems to increase during clinical training, but research investigating this in veterinary students is scarce. According to transactional stress theory, individual students may not perceive every stressor as equally stressful.
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- Chronic rhinosinusitis (CRS) negatively affects patients’ quality of life and healthcare costs; understanding pathogen trends can enhance treatment.
- The study aimed to identify and compare common pathogens linked to CRS across three periods: pre-pandemic, during-pandemic, and post-pandemic.
- Results indicated 46 different organisms were found, with notable increases in the prevalence of specific pathogens during and after the COVID-19 pandemic, highlighting shifts in CRS-related infections.
Article Synopsis
- Molecular testing of thyroid nodules helps identify genetic changes that can indicate the risk of cancer aggressiveness and behavior.
- The study looked at patients from 2017 to 2024, focusing on those with specific mutations and analyzing their association with aggressive thyroid cancer types.
- Results showed that patients with both TEL mutations and concurrent alterations were more likely to have high-risk features and aggressive cancer forms, while TEL mutations alone showed a tendency for less aggressive behavior.