[The current concept of immunological disorders in the case of basal-cell carcinoma].

Imbalance in the interaction of mechanisms of innate and adaptive immunity rather than selective defect of each of the links is a determinant of the development of basal-cell carcinoma of this or that form of immunopathology or that of transformation of one to another form. The lecture gives notions on immunological phenotypes and the parameters of innate and adaptive immunity and on the association of two links of immunity. The major tumor-associated immunological phenotypes are pathogenetically and clinically different, but have signs of two-link immunodeficiency in each case.

[Matrix metalloproteinases and their tissue inhibitors in basal cell and metatypical cancer of the skin].

10 cases of ulcerative-nodular basal cell carcinoma and 10 cases of metatypical carcinoma of the skin were studied immunohistochemically for immunoexpression of matrix metalloproteinases (MMP-1, MMP-9) and their endogenic tissue inhibitors (TIMP-1, TIMP-2) in combination with PCNA, p53 tumor complexes. Some differences are found in these types of tumors.

[Modern programs of treatment and rehabilitation of patients with basaliomas: their pathogenic substantiation and clinical effectiveness].

With the aim of forming modern programs for immunogenetic therapy of epithelial tumors, such as methatypic and basal cell carcinomas, the authors of the article analyze the basics of their immunopathogenesis. Having considered the latest immunotherapy regimens, the authors present their clinical assessment.

[Differential diagnosis and treatment of metatypic cancer].

Fifty one patients with metatypic carcinoma (MC), 10 with basalioma, and 10 with squamous cell carcinoma were clinically and immuno-morphologically studied. There were great differences in the localization of basal cell antigen in the epidermis during MC, basalioma, squamous carcinoma of the skin. Expression of fixed immunoglobulins A, M, G in tumor tissues revealed no significant differences.