CCG-1423-derived compounds reduce global RNA synthesis and inhibit transcriptional responses.

Myocardin-related transcription factors (MRTFs) are coactivators of serum response factor (SRF), and thereby regulate cytoskeletal gene expression in response to actin dynamics. MRTFs have also been implicated in transcription of heat shock protein (HSP)-encoding genes in fly ovaries, but the mechanisms remain unclear. Here, we demonstrate that, in mammalian cells, MRTFs are dispensable for gene induction of HSP-encoding genes.

[The possibility of diagnosing the prescription of death in the study of embalmed corpses by the method of spin probes. (Experimental study)].

Is to establish the possibility of studying the vitreous body of the eye from embalmed corpses using the spin probe method to develop diagnostic criteria for the prescription of death coming. The article presents data showing the possibility of diagnosing the prescription of death coming by the method of spin probes with the examination of the vitreous body of the eye from embalmed corpses. A total of 510 spectra obtained during incubation of the 1-oxyl-4-oxo-2.

[History of the department of forensic medicine, named after P.A. Minakov of the medical faculty of the Pirogov Russian national research medical university].

The article is devoted to the history of the formation and development of the department of forensic medicine named after P.A. Minakov of the medical faculty of the Pirogov russian national research medical university for 115 years.

Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity.

Myocardin-related transcription factor A (MRTF-A), a coactivator of serum response factor (SRF), regulates the expression of many cytoskeletal genes in response to cytoplasmic and nuclear actin dynamics. Here we describe a novel mechanism to regulate MRTF-A activity within the nucleus by showing that lamina-associated polypeptide 2α (Lap2α), the nucleoplasmic isoform of Lap2, is a direct binding partner of MRTF-A, and required for the efficient expression of MRTF-A/SRF target genes. Mechanistically, Lap2α is not required for MRTF-A nuclear localization, unlike most other MRTF-A regulators, but is required for efficient recruitment of MRTF-A to its target genes.

[Features of the architectonics of the structures of the nasal cavity and choanal zone in children with congenital malformations of the eyes].

The article provides data on the embryogenesis of the eyeball, nasolacrimal canal and nasal cavity. A frequent combination of congenital choanal atresia and anomalies in the development of the eyes was noted, most likely associated with the temporal and topographic parallelism of the intrauterine development of these anatomical areas. In order to assess the condition of the nasal cavity and choanal region in congenital eye pathology, 43 children with ophthalmological malformations were examined.