[Platelet glutathione reductase and glutathione-S-transferase in elderly patients with depression].

Objective: To compare the activity of platelet glutathione reductase (GR) and glutathione-S-transferase (GST) in elderly patients with depression and in the control group, and to identify a possible relationship between the activity of these enzymes and clinical parameters of the disease.

Material And Methods: We examined 42 elderly patients (60-86 years old) with depressive episodes of various nosological categories according to ICD-10: a single depressive episode (F32.0, F32.

[The link of platelet cytochrome C-oxidase activity with some clinical parameters of depression in elderly patients].

Objective: To search for correlations between platelet cytochrome c-oxidase (COX) activity and the quality of therapeutic outcomes and other clinical parameters of depression in elderly patients.

Material And Methods: Twenty elderly women, aged 55-78 years, with depressive episodes in recurrent depressive disorder (RDD) or bipolar affective disorder (BD) were studied. COX activity and severity of depression were evaluated twice: before the beginning of antidepressant treatment and at the 28-th day of the therapy, using the Hamilton Depression Rating Scale (HAMD-17) and the Hamilton Anxiety Rating Scale (HAM-A).

[The influence of nooclerin on the structure of sleep disturbances in children with tension headaches].

Aim: To study the effects of nooclerin (deanol aceglumate) on the structure of sleep disturbances in children with tension-type headache (TTH).

Material And Methods: A blind randomized placebo-controlled study of the efficacy of nooclerin (deanol aceglumate), prescribed for 2 months to prevent TTH, was carried out. The study included 60 patients (30 boys and 30 girls), aged 9-16 years, with TTH.

[Augmentation with carnicetine for late depression].

Aim: Comparative evaluation of the efficacy and safety of antidepressant monotherapy and complex antidepressant therapy in combination with carnicetine in the treatment of depression in elderly patients in a psychiatric hospital.

Material And Methods: Two groups of hospitalized patients, aged from 60 to 79 years, with mild or moderate depression (according to ICD-10), comparable in basic demographic and clinical characteristics, received mono- or complex (in combination with carnicetine) antidepressant therapy for 8 weeks. Treatment efficacy was assessed with HAM-D, HARS, CGI-S and CGI-I; the level of cognitive activity was assessed with MMSE, the 10-word memory test and clock drawing test.

[Tension type headaches in children and adolescents: co-morbidity with emotional and behavioral disorders].

Aim: To assess the incidence of emotional and behavioral disorders in children and adolescents with frequent episodic or chronic tension type headaches (TTH).

Material And Methods: One hundred and fifty patients with TTH (75 boys and 75 girls), aged 8-16 years, were included in the study. The severity of emotional and behavioral problems was analyzed in comparison with their healthy peers by means of parents' interviewing with the 'Strengths and Difficulties Questionnaire' (SDQ).