Glucose homeostasis during the early stages of liver regeneration in fasted rats.

Kinetic studies with [2-3H]glucose in vivo and gluconeogenic activity measurements in vivo and in vitro were performed in 70% hepatectomized rats submitted to fasting, which represents an extra burden for glucose synthesis but does not impair liver regeneration. Rates of glucose replacement, under steady-state conditions, 14 and 24 h postoperatively, did not differ in partially hepatectomized fasted rats and sham-operated controls. Phosphoenolpyruvate carboxykinase activities increased more rapidly during fasting in remnant livers than in intact livers from controls.

Effects of fasting and adrenalectomy on the kinetics of glucose metabolism in granivorous and carnivorous birds.

1. [1-(14)C]-Glucose was used to estimate the rate of glucose replacement and of hexose recycling via 3-carbon compounds in fed, fasted and fasted-adrenalectomized granivorous (chickens) and carnivorous (black vultures) birds. 2.

Fasting, adrenalectomy, and gluconeogenesis in the chicken and a carnivorous bird.

Previous studies showed that livers from carnivorous birds have a higher gluconeogenic capacity and higher levels of gluconeogenic enzymes than livers from granivorous birds. In this work we compare the effects of fasting and adrenalectomy on gluconeogenesis. Fasting in the chicken elicited increased rates of incorporation of 14C from alanine into blood glucose, increased gluconeogenesis in liver slices, and increased activities of four gluconeogenic enzymes: glucose-6-phosphatase, phosphoenolpyruvate carboxykinase, alanine aminotransferase, and aspartate aminotransferase.