Bacteria in nature can exist in multicellular communities called biofilms. Biofilms also form in the course of many infections. infections frequently involve biofilms, which contribute materially to the difficulty to treat these infections with antibiotic therapy.
View Article and Find Full Text PDFAssembly of NADPH oxidase 2 (NOX2) proteins in neutrophils plays an essential role in controlling microbial infections by producing high levels of reactive oxygen species (ROS). In contrast, the role of the Hv1 voltage-gated proton channel that is required for sustained NOX2 activity is less well characterized. We examined the role of Hv1 in a murine model of blinding corneal infection and found that in contrast to C57BL/6 mice, mice exhibit an impaired ability to kill bacteria and regulate disease severity.
View Article and Find Full Text PDFIntroduction: Without explicit education and training on how social determinants of health (SDoH) impact patient care and health outcomes, medical schools are failing to effectively equip future physicians to serve their patients. We created this workshop on health equity with a focus on SDoH to help students more effectively communicate with diverse populations.
Methods: Third-year medical students and faculty were provided with class guides, learning objectives, role-play vignettes containing clerkship-specific history and physical exams, schedules, and discussion questions during a 2-hour session centered on SDoH.